Publications

First experience with 224Radium-labeled microparticles (Radspherin®) after CRS-HIPEC for peritoneal metastasis in colorectal cancer (a phase 1 study). S. Larsen , W. Graf, A. Mariathasan, O. Sørensen, M. Spasojevic, M. Goscinski, S. Selboe, N. Lundstrøm, A. Holtermann, M. Revheim and Ø. Bruland. March 2023
Intraperitoneal alpha therapy with 224Ra-labeled microparticles combined with chemotherapy in an ovarian cancer mouse model. Wouters R, Westrøm S, Berckmans Y, Riva M, Ceusters J, Bønsdorff TB, Vergote I, Coosemans A. Front Med (Lausanne). 2022 Oct
Effect of Particle Carriers for Intraperitoneal Drug Delivery on the Course of Ovarian Cancer and Its Immune Microenvironment in a Mouse Model. Wouters R, Westrøm S, Vankerckhoven A, Thirion G, Ceusters J, Claes S, Schols D, Bønsdorff TB, Vergote I, Coosemans A. Pharmaceutics. 2022 Mar
An Experimental Generator for Production of High-Purity 212Pb for Use in Radiopharmaceuticals. Li RG, Stenberg VY, Larsen RH. J Nucl Med. 2023 Jan Epub 2022 Jul 7
A Novel Single-Step-Labeled 212Pb-CaCO3 Microparticle for Internal Alpha Therapy: Preparation, Stability, and Preclinical Data from Mice. By Ruth Gong Li, Kim Lindland, Tina Bjørnlund Bønsdorff, Sara Westrøm and Roy Hartvig Larsen
Radon-220 diffusion from 224Ra-labeled calcium carbonate microparticles: Some implications for radiotherapeutic use. By Elisa Napoli, Tina B Bønsdorff, Ida Sofie Jorstad, Øyvind S Bruland, Roy H Larsen, Sara Westrøm
Improved Formulation of 224Ra-Labeled Calcium Carbonate Microparticles by Surface Layer Encapsulation and Addition of EDTMP. By Ruth Gong Li, Kim Lindland, Sandra Karen Tonstad, Tina Bjørnlund Bønsdorff, Asta Juzeniene, Sara Westrøm and Roy Hartvig Larsen(external link)
Calcium Carbonate Microparticles as Carriers of 224Ra: Impact of Specific Activity in Mice with Intraperitoneal Ovarian Cancer. By Ruth Gong Li, Elisa Napoli, Ida Sofie Jorstad, Tina Bjørnlund Bønsdorff, Asta Juzeniene, Øyvind Sverre Bruland, Roy Hartvig Larsen, Sara Westrøm (external link)
Ra-224 activity, half-life, and 241 keV gamma ray absolute emission intensity: A NIST-NPL bilateral comparison. By Denis E.Bergeron, Sean M.Collins, Leticia Pibida, Jeffrey T. Cessn, Ryan Fitzgerald, Brian E. Zimmerman, Peter Ivanov, John, D. Keightley, Elisa Napoli (external link)
Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples. By Author Elisa Napoli, Vilde Y. Stenberg, Asta Juzeniene, Gro E. Hjellum, Øyvind S. Bruland, Roy H. Larsen (external link)
Radionuclide calibrator responses for 224Ra in solution and adsorbed on calcium carbonate microparticles. By Elisa Napoli, Jeffrey T.Cessna, Leticia Pibida, Ryan Fitzgerald, Gro E.Hjellum, Denis E. Bergeron
Primary standardization of 224RA activity by liquid scintillation counting. Elisa Napoli, Jeffrey T. Cessna, Ryan Fitzgerald, Leticia Pibida, Ronald Collé, Lizbeth Laureano-Pérez, Brian E. Zimmerman, Denis E.Bergeron; Applied Radiation and Isotopes Volume 155, January 2020, 108933 (external link)
Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice. Westrøm S, Malenge M, Jorstad IS, Napoli E, Bruland Ø, Bønsdorff TB, Larsen R; J Labelled Comp Radiopharm. 2018 May 30;61(6):472-486.
Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma. Westrøm S, Bønsdorff TB, Abbas N, Bruland ØS, Jonasdottir TJ, Mælandsmo GM, Larsen RH. PLoS One. 2016 Oct 24;11(10)
Therapeutic Effect of α-Emitting 224Ra-Labeled Calcium Carbonate Microparticles in Mice with Intraperitoneal Ovarian Cancer. Westrøm S, Bønsdorff TB, Bruland ØS, Larsen RH. Translational Oncology. 2018 Jan 27;11:259-267
Preparation of 212Pb-labeled monoclonal antibody using a novel 224Ra-based generator solution. Westrøm S, Generalov R, Bønsdorff TB, Larsen RH. Nuclear Medicine and Biology. 2017 Apr 26;51:1-9
Release and retention of 212Pb from 224Ra-labeled microparticles. Napoli E, Westrøm S, Bønsdorff TB, Bruland Ø, Larsen R.; The Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2018 Annual Meeting in Philadelphia, USA

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Jan Alan Alfheim

Chief Executive Officer

alfheim@oncoinvent.com

+47 464 40 045

Jan A. Alfheim is a business executive with over thirty years’ experience bringing product ideas and technology to the chemical and pharmaceutical markets, from product concept inception through discovery and development phases to final marketing campaign and launch.

With experience in research, project management, business development & partnering, company start-ups, and product launches, Alfheim comes from Nordic Nanovector ASA where he was Chief Executive Officer from 2011 until 2014 and Chief Operating Officer from 2014 to 2016. Prior to working at Nordic Nanovector, he has held various senior roles including Chief Business Officer at Clavis Pharma, President of StemPath Inc, Director of Business Development at Neurochem Inc and Project Director at Nycomed Imaging. Mr. Alfheim holds a MSc from Concordia University and a MBA from McGill University.

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